Pedro J.  del Nido , MD

Boston Magazine Top Doctors 2011 , December 2011

Boston Magazine

Emani SM, Bacha EA, McElhinney DB, Marx GR, Tworetzky W, Pigula FA, del Nido PJ

Primary left ventricular rehabilitation is effective in maintaining two-ventricle physiology in the borderline left heart

J Thorac Cardiovasc Surg  Issue: 138(6) , Page: 1276-82

Geva T, Gauvreau K, Powell AJ, Cecchin F, Rhodes J, Geva J, del Nido P.

Randomized trial of pulmonary valve replacement with and without right ventricular remodeling surgery

Circulation  Issue: 122(11 Suppl) , Page: S201-8

Tang D, Yang C, Geva T, Gaudette G, del Nido PJ

Multi-Physics MRI-Based Two-Layer Fluid-Structure Interaction Anisotropic Models of Human Right and Left Ventricles with Different Patch Materials: Cardiac Function Assessment and Mechanical Stress Analysis

Comput Struct  Issue: 89(11-12) , Page: 1059-1068

Vasilyev NV, Kawata M, Dibiasio CM, Durand KV, Hopkins J, Traina ZJ, Slocum AH, del Nido PJ

A novel cardioport for beating-heart, image-guided intracardiac surgery , 2011 Aug 18 [Epub ahead of print]

J Thorac Cardiovasc Surg

Vida VL, Hoehn R, Larrazabal LA, Gauvreau K, Marx GR, del Nido PJ., del Nido PJ

Usefulness of intra-operative epicardial three-dimensional echocardiography to guide aortic valve repair in children , 2009

Am J Cardiol  Issue: 103(6) , Page: 852-6

Bacha EA, Larrazabal LA, Pigula FA, Gauvreau K, Jenkins KJ, Colan SD, Fynn-Thompson F, Mayer JE Jr, del Nido PJ

Measurement of technical performance in surgery for congenital heart disease: the stage I Norwood procedure , 2008

J Thorac Cardiovasc Surg , Page: 993-7

NARRATIVE REPORT OF RESEARCH, TEACHING AND CLINICAL CONTRIBUTIONS

My laboratory research work has focused on two areas related cardiac surgery:

The first area involves investigation of mechanisms responsible for the development of heart failure in hypertrophy. Currently, my work includes: investigation of mechanisms responsible for decreased tolerance to ischemia in hypertrophied myocardium and the role angiogenesis plays in progression of hypertrophy to heart failure.

The second area of investigation aims to develop techniques for performing reconstructive surgery inside the beating heart using 3-D echocardiography. This project is a research partnership between ourselves, two engineering laboratories and industry and proposes to design and implement new technology and instrumentation to facilitate repair of intracardiac defects in the beating heart, thus obviating the need for open heart surgery.

FUNDING INFORMAITON (* active grants)

2003-2008* National Institutes of Health (NHLBI)
Principal Investigator
Image Guided Intracardiac Beating Heart Surgery
Bioengineering Research Partnership
(RO1 HL073647)

2004-2009* National Institutes of Health (NHLBI)
Principal Investigator
Angiogenesis, Cardiac Hypertrophy and Surgical Ischemia
(RO1 HL63095)

REPORT OF CURRENT RESEARCH ACTIVITIES

Image Guided Intracardiac Beating Heart Surgery
This a Bioengineering Research Partnership to develop novel imaging techniques and instrument modification for performing reconstructive surgery inside the beating heart. The partnership includes two engineering laboratories (Dupont-Boston U.; Howe-Harvard DEAS), and industry (Philips Medical Systems) working on modification of ultrasound imaging hardware, image processing, instrument modification, and device development.
Role – Principal Investigator

Angiogenesis, Cardiac Hypertrophy and Surgical Ischemia
This project aims to study the role of Hypoxia Inducible factor in capillary growth during the progression of pressure overload hypertrophy.
Role – Principal Investigator.

Pedro del Nido, MD, Research site