Alan B.  Cantor , MD, PhD

Woo A, Moran TB, Choe S-K, Schindler Y., Sullivan MR, Fujiwara Y, Paw BH, Cantor AB

Identification of ZBP-89 as a Novel GATA-1 Associated Transcription Factor Involved in Megakaryocytic and Erythroid Development , 2008

Mol. Cell. Bio. PMC ID: PMC2293107.  Issue: 28 , Page: 2675-2689.

Bai, X, Kim J, Yang Z, Jurynec MJ, Akie TE, Lee J, LeBlanc J, Sessa A, Hong J, DiBiase A, Zhou Y, Grunwald DJ, Lin S, Cantor AB, Orkin SH, Zon LI.

TIF1γ controls erythroid cell fate by regulating transcription elongation. , 2010

Cell. PMID: 20603019.  Issue: 142 , Page: 133-143

Huang H, Yu M, Akie TE, Moran TB, Woo AJ, Tu N, Waldon Z, Lin YY, Steen H, Cantor AB

Differentiation-dependent Interactions between RUNX-1 and FLI-1 During Megakaryocyte Development , May 26, 2009

Mol. Cell. Bio. [Epub ahead of print]. PMCID: PMC2715817.  Issue: 29 , Page: 4103-15

Kim J, Woo AJ, Chu J, Snow J, Fujiwara Y, Kim CG, Cantor AB, Orkin SH.

Separable core pluripotency, polycomb, and Myc network modules in embryonic stem cells and cancer. , 2010

Cell. PMID: 20946988.  Issue: 143 , Page: 184-6

Yu M, Riva L, Xie H, Schindler Y, Moran TB, Cheng Y, Yu D, Hardison R, Weiss MJ, Orkin SH, Bernstein BE, Fraenkel E, Cantor AB.

Novel Insights into GATA-1 Mediated Gene Activation versus Repression via Genome-wide Chromatin Occupancy Analysis. , 2009

Molecular Cell. NIHMS:163436. PMCID: PMC2800995.  Issue: 36 , Page: 682-695

Cantor AB.

GATA transcription factors in hematologic disease , 2005 Jun

Int J Hematology  Issue: 81(5) , Page: 378-84

Cantor AB, Orkin SH.

Coregulation of GATA factors by the Friend of GATA (FOG) family of multitype zinc finger proteins. , 2005 Feb

Semin Cell Dev Biol  Issue: 16(1) , Page: 117-28

Sankaran VG, Menne TF, Xu J, Akie TE, Lettre G, Handel BV, Mikkola, HKA, Hirshhorn JN, Cantor AB, Orkin SH.

Human Fetal Hemoglobin Expression is Regulated by the Developmental Stage- specific Repressor BCL11A. , 2008

Science. PMCID: PMC2854393.  Issue: 322 , Page: 1839-1842

Huang H, Cantor AB

Common Features of Megakaryocytes and Hematopoietic Stem Cells: Whats the Connection? , 2009

J Cell Biochem [Epub ahead of print]  Issue: 107 , Page: 857-64

Alan Cantor's laboratory is focused on further elucidating the transcriptional mechanisms that regulate normal hematopoiesis and how perturbetheir dysregulation contributes to malignancieshuman leukemogenesis. This includes studies examining interactions between hematopoietic transcription factors and epigenetic regulators. Cantor and colleagues are particularly interested in the role of GATA, RUNX and ETS transcription factor family members in hematopoiesis. The Cantor laboratory is currently taking fourt approaches to further understand the roles of these transcription factors in megakaryopoiesis, erythropoiesis, and hematologic malignancy. The first is to isolate and characterize stable multiprotein complexes involving these factors. The second involves genome-wide identification of target genes of these factors (and their cis-regulatory elements) by a chromatin immunoprecipitation-DNA sequencing techniques. The third utilizes conditional gene knocik-out technology in mice. The fourth involves human genetic studies of families with inherited thrombocytopenias and propensity for the development of myelodysplastic syndrome and leukemia.

Transcription Factors in Erythropoiesis and Megakaryopoiesis

• Yu M, Riva L, Xie H, Schindler Y, Moran TB, Cheng Y, Yu D, Hardison R, Weiss MJ, Orkin SH, Bernstein BE, Fraenkel E, Cantor AB. 2009. Novel Insights into GATA-1 Mediated Gene Activation versus Repression via Genome-wide Chromatin Occupancy Analysis. Molecular Cell, 36: 682-695.NIHMS:163436. PMCID: PMC2800995
• Sankaran VG, Menne TF, Xu J, Akie TE, Lettre G, Handel BV, Mikkola, HKA, Hirshhorn JN, Cantor AB, Orkin SH. 2008. Human Fetal Hemoglobin Expression is Regulated by the Developmental Stage-specific Repressor BCL11A. Science 322:1839-1842. PMID: 1905693
• Huang H, Yu M, Akie TE, Moran TB, Woo AJ, Tu N, Waldon Z, Lin YY, Steen H, Cantor AB. 2009. Differentiation-dependent Interactions between RUNX-1 and FLI-1 During Megakaryocyte Development, Mol. Cell. Bio. 29::4103-15. PMCID: PMC2715817
• Woo A, Moran TB, Choe S-K, Schindler Y., Sullivan MR, Fujiwara Y, Paw BH, Cantor AB. 2008. Identification of ZBP-89 as a Novel GATA-1 Associated Transcription Factor Involved in Megakaryocytic and Erythroid Development. Mol. Cell. Bio. 28:2675-2689. PMC ID: PMC2293107.

Research website for Alan Cantor, MD, PhD

Children's Hospital Boston at Waltham