Stuart H. Orkin , MD

	Associate Chief, Division of Hematology/Oncology, Children's Hospital Boston Chairman, Pediatric Oncology Office Phone: 617-919-2042 Appointment Line: 1-888-PEDI-ONC (733-4662) Fax: 617-730-0222 Email this provider NPI: 1558409961

Associate Chief, Division of Hematology/Oncology, Children's Hospital Boston
Chairman, Pediatric Oncology

Office Phone: 617-919-2042

Appointment Line: 1-888-PEDI-ONC (733-4662)

Fax: 617-730-0222

NPI: 1558409961

pediatric hematology

pediatric oncology

David G. Nathan Professor of Pediatrics, Harvard Medical School

Pediatrics

Harvard Medical School, Boston, MA (1972)

Children's Hospital Boston, Boston, MA (07/72 to 06/73)

Children's Hospital Boston, Boston, MA (07/74 to 06/76)

Children's Hospital Boston, Boston, MA (07/76 to 06/78)

Developmental Biology of Blood, Blood Vessels and Heart, Cancer Biology, Stem Cell Biology

Role of GATA-1, GATA-2 and other transcription factors (SCL, NF-E2, EKLF, BKLF, RBTN2, VAV, TEL, SHP﷓2, SP1) in mammalian blood cell and blood vessel formation (Nature 374:470, 1995, Nature 375:318, 1995, Cell 86:47, 1996; Cell 90:109, 1997; Genes Dev 12:473, 1998; Genes Dev 12:2392, 1998; Nat Genet 24:266, 2000; Genes Dev 16:301,2002; J Exp Med 195:1387, 2002 and 197:281, 2003; Immunity 18:109, 2003; Proc Natl Acad Sci USA 100:14030, 2003; Genes Dev 18:2336, 2004)
Role of GATA factor-interacting proteins in blood and heart development (Cell 90:109, 1997; Cell 101:729, 2000; Genes Dev 15:839, 2001)
Platelet formation (Cell 81:695, 1995; Genes Dev 12:1176, 1998; Mol Cell Biol 22:4268, 2002; Proc Natl Acad Sci USA 99:9237, 2002)
Control of globin transcription (Proc Natl Acad Sci USA 97:7172, 2000)· Function of peroxiredoxin (Nature 424: 561, 2003)
Role of GATA-1 mutations in transient myeloproliferative syndrome of Down's neonates (Nat Genet 37:613, 2005)
Factors involved in stem cell formation and function and stem cell niches (Nature 421:547, 2003; Nature 431:1002, 2004; Dev Cell 8:365, 2005)

Research site for Stuart Orkin, MD

Molecular Hematopoiesis, Cancer and Stem Cell Biology (some recent papers)

Hematopoiesis: Roles of transcription factors in development and function of hematopoietic stem cells and progenitors (Proc. Natl. Acad. Sci. USA 103:9057,2006; J. Biol. Chem. 281:13733, 2006; Blood 107:3527,2006; Dev Cell 8:365,2005
Leukemia: Roles of somatically mutated transcription factors in human leukemias (Nat Genet. 37:613, 2005; Proc. Natl. Acad. Sci USA 103:3339, 2006)
Stem Cell Biology: Studies of hematopoietic stem cells and embryonic stem cells (Cell 122:828, 2005; Nature 431:1002, 2004; Genes Dev 18:2336, 2004