Leonard I.  Zon , MD
Office Phone: 617-919-2069
Appointment Line: 1-888-PEDI-ONC (733-4662)
Fax: 617-730-0222
NPI: 1245299197

Departments/Divisions

Specialties

Hematology
aplastic anemia
congenital anemias
hematology
hematology/oncology
hematopoietic stem cell transplantation

Services/Programs

Academic Appointments

Grousbeck Professor of Pediatrics, Harvard Medical School

Certifications

Internal Medicine, Hematology

Medical School

Thomas Jefferson University, Philadelphia, PA  (1983)

Internship

New England Deaconess Hospital, Boston, MA  (07/83 to 06/84)

Residency

New England Deaconess Hospital, Boston, MA  (07/84 to 06/86)

Fellowship

Dana-Farber Cancer Institute, Boston, MA  (07/86 to 06/89)

Publications

White RM , Sessa A, Burke C, Bowman T, LeBlanc J, Ceol C, Bourque C, Dovey M, Goessling W, Burns CE, Zon LI.
. Transparent adult zebrafish as a tool for in vivo transplantation analysis. , 2008
Cell Stem Cell , Page: 2:183-189
North TE, Goessling W, Peeters M, Li P, Lord AM, Dzierzak E, and Zon LI
Hematopoietic stem cell development is dependent on blood flow and nitric oxide signaling. , 2009, May 15
Cell , Page: 137(4):736-748.
North TE, Goessling W, Walkley CR, Lengerke C, Kopani KR, Lord AM, Weber G, Jang IH, Grosser T, FitzGerald GA, Daley GQ, Orkin SH, and Zon LI.
Prostaglandin E2 regulates vertebrate hematopoietic stem cell homeostasis , 2007
Nature , Page: 447:1007-1011
Goessling W, North TE, Loewer S, Lord AM, Sang L, Stoick-Cooper C, Weidinger G, Puder M, Daley GQ, Moon RT, and Zon LI.
Genetic interaction between PGE2 and wnt signaling regulates developmental specification of stem cells and regeneration. , March 20, 2009
Cell , Page: 136:1136-1146
Stem Cells, Developmental Baiology of Blood and Blood Vessels, Cancer Genetics in Zebrafish
  • Characterization of genes required to form stem cells (Nature 425:300, 2003)
  • Characterization of genes required for formation of blood cells and blood vessels from mesoderm in zebrafish and frogs (Nature 382:357, 1996; Immunity 7:325, 1997; Genes Dev 12:621, 1998; Development 125:2611, 1998; Development 128:2301, 2001; Development 129:649, 2002 and 129:4359, 2002; Science 295:457, 2002; Cell 108:731, 2002; PLoS Biol. 2:E237, 2004; Dev Cell 8:109, 2005; Genes Dev 19:2331, 2005)
  • Characterization of models of human anemias in zebrafish (Nat Genet 20:244, 1998; Development 127:5123, 2000; Nature 403:776, 2000; Nat Genet 34: 59, 2003; Development 131:6225, 2004; J Clin Invest 115:1532, 2005)
  • Identification of new genes involved in iron transport and hemoglobin formation. (Nature 403:776, 2000; Blood 100:4655, 2002; J Clin Invest 115:1532, 2005; Nature 436:1035, 2005; Nature 440:96, 2006
  • Cancer genetics using zebrafish (Cancer Cell 1:229, 2002; Science 299:887, 2003; Proc Natl Acad Sci USA 102:407, 2005; Curr Biol 15:249, 2005; Proc Natl Acad Sci USA 102:13194,2005)
  • Role of SUMOylation and the promyelocytic leukemia (PML) gene in transcription (Mol Cell 10:831 and 10:843, 2002)
  • Transplantation and in vivo imaging in zebrafish (Nat Immunol 4: 1238, 2003)
  • T cell development in zebrafish (Immunity 20:367, 2004; Proc Natl Acad Sci USA 101:7369, 2004)
  • Hematopoietic stem cell transplantation in zebrafish (Blood 104:1298, 2004)
  • Chemical suppresor screens (Nat Chem Biol 1:366, 2005)

  • Children's Hospital Boston
    Division of Hematology/Oncology
    300 Longwood Avenue
    Karp 07210
    Boston, MA  02115
    Phone: 617-919-2069
    Fax: 617-730-0222
schedule an appointment
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