George Q. Daley , MD, PhD
Director of Stem Cell Transplantation
Office Phone: 617-919-2015
Appointment Line: 1-888-PEDI-ONC (733-4662)
hematopoietic stem cell transplantation
Samuel E. Lux, IV Professor of Hematology, Children's Hospital Boston, Harvard Medical School
Harvard University , Cambridge , MA (1982)
Ph.D., MIT, Cambridge, MA (1989)
Harvard Medical School , Boston , MA (1991)
Mass General Hospital , Boston , MA (1991-92)
Mass General Hospital , Boston , MA (1992-95)
Research Fellowship, Whitehead Institute for Biomedical Reseach (1995-2003)
Clinical Fellowship Hematology/Oncology, Children's Hospital Boston, Dana Farber Cancer Institute, and Brigham Women's Hospital, Boston, MA
Whitehead Institute for Biomedical Research, Cambridge , MA (1995-2003)
E. Mead Johnson Award , 2009
American Pediatric Society and Society for Pediatric Research
Directed differentiation of HSCs from pluripotent stem cells: We study hematopoietic development in mouse embryos and differentiating cultures of human and mouse pluripotent stem cells to define the molecular genetic programs that enable formation of HSCs in experimental and therapeutic models. Our long-term goal is improved transplantation therapies for genetic and malignant blood disorders.
Derivation of genetically defined pluripotent stem cells: We use nuclear transfer, parthenogenesis, and reprogramming with defined genes to model combined cell and gene therapy of human genetic disorders.
Mechanisms of oncogenesis: We have a long-standing interest in molecular mechanisms of leukemia induction by the BCR/ABL oncoprotein in human Chronic Myeloid Leukemia, the classic malignancy of hematopoietic stem cells. Recent studies in our lab have focused on the role of the Lin28A/B genes that are linked to a variety of cancer types.
Research site for George Daley, MD, PhD
Children's Hospital Boston300 Longwood AvenueKarp 7214Boston, MA 02115Phone: 617-919-2015Fax: 617-730-0222