Loren D. Walensky , MD, PhD

	Office Phone: 617-632-6794 Appointment Line: 1-888-PEDI-ONC (733-4662) Fax: 617-582-8240 Email this provider NPI: 1508896853

Office Phone: 617-632-6794

Appointment Line: 1-888-PEDI-ONC (733-4662)

Fax: 617-582-8240

NPI: 1508896853

hematology/oncology

Associate Professor of Pediatrics, Harvard Medical School

Pediatrics, Pediatric Hematology/Oncology

Johns Hopkins University School of Medicine, Baltimore, MD

Pediatrics, Boston Combined Residency Program, Children's Hospital Boston/Boston Medical Center, Boston, MA

Pediatric Hematology/Oncology, Children's Hospital Boston/Dana-Farber Cancer Institute, Boston, MA

Molecular Oncology, Cancer Chemical Biology, Apoptosis, Developmental Therapeutics

Design and synthesis of a chemically-stabilized peptide helix of the pro-apoptotic protein BID for the treatment of leukemia. (Science 305: 1466-70, 2004)
Discovery of a trigger site on the pro-apoptotic protein BAX, a novel target for therapeutic modulation of cell death. (Nature 455: 1076-81, 2008)
Chemical and structural dissection of the binding and selectivity determinants for targeting anti-apoptotic MCL-1 in cancer. (Nature Chemical Biology 6: 595, 2010)
Development of a novel double-stapling method for remedying the proteolytic instability of lengthy peptide therapeutics. (Proceedings of the National Academy of Sciences 107: 14093-8, 2010)
Biochemical and structural elucidation of the stepwise mechanism for direct activation of pro-apoptotic BAX. (Molecular Cell 40:481, 2010)
Design and characterization of a stapled p53 helix to overcome HDMX-mediated suppression of p53 in human cancer. (Cancer Cell 18: 411-22, 2010)
Development of photoreactive stapled peptides as a novel protein capture technology for proteomic discovery. (Chemistry and Biology 17: 1325-33, 2010)