Arin K. Greene , MD, MMSc
Office Phone: 617-355-2306
Appointment Line: 617-355-2306
Fax: 617-730-0752NPI: 1053385245
One-fourth of Dr. Greene's academic time is protected for research, and he is responsible for directing our department's research laboratory. His primary research effort is focused on vascular malformations/lymphedema, a group of congenital disorders that affect arteries, capillaries, lymphatics, or veins. These lesions cause significant morbidity because they enlarge over time and recur after treatment. Currently, drugs are not available for patients with vascular malformations. Clinically, Dr. Greene is reviewing the vascular anomalies database to determine the progression and recurrence rate of these lesions, as well as factors that contribute to progression and recurrence. In the laboratory, he is investigating the pathophysiology of vascular malformations by studying resected clinical tissue. Dr. Greene's second area of research study is pediatric cranioplasty using autologous calvarial particulate bone graft. Cranioplasty in young children is difficult because of limited donor sites and the reluctance to use alloplastic materials in the growing skeleton. The department has developed a novel bone grafting technique (particulate graft) that may be harvested from the cranium as early as infancy. We have shown that particulate bone graft effectively prevents as well as treats cranial defects in children. Dr. Greene is translating these clinical findings to the laboratory to investigate the efficacy of particulate bone grafting for onlay cranioplasty. In addition, he is determining the osteogenic, osteoinductive, and osteoconductive properties of particulate bone graft, and is comparing it to other types of grafting material.