Departments/Divisions
Specialties
aplastic anemia
blood formation
gene therapy
chronic granulomatous disease
Fanconi anemia and other genetic disorders
hematopoiesis
neutropenia and neutrophil dysfunction syndromes
stem cell biology
viral vectors
Services/Programs
Academic Appointments
Leland Fikes Professor of Pediatrics, Harvard Medical School
Certifications
Pediatrics
Date Appointed
December 03, 2007
Expanded Biography
David A. Williams, age 55, is a graduate of Indiana State University and Indiana University School of Medicine. After training in Pediatrics at Cincinnati Childrens Hospital Medical Center (CCHMC), Dr. Williams completed fellowship training in Pediatric Hematology/Oncology at Childrens Hospital Boston/Dana-Farber Cancer Institute. He completed his research training at the Cancer Center and Whitehead Institute at the Massachusetts Institute of Technology, and then became a faculty member at Harvard Medical School and of the Howard Hughes Medical Institute (HHMI).
Dr. Williams returned to Indiana and served for ten years as the inaugural director of the Herman B Wells Center for Pediatric Research at Indiana University School of Medicine. In 2002, Dr. Williams left join to join Cincinnati Childrens Hospital Medical Center (CCHMC) as the Director of the Division of Experimental Hematology and attending physician in Hematology/Oncology in the Department of Pediatrics, where he stayed until 2007. Dr. Williams also served as the Associate Chair for Translational Research at CCHMC and Deputy Director of the University of Cincinnati Cancer Center from 2002-2006. He is currently the Chief, Division of Hematology/Oncology and Director of Clinical and Translational Research, Childrens Hospital Boston and the Leland Fikes Professor of Pediatrics, Harvard Medical School.
Dr. Williams served five years on Subcommittee A for Comprehensive Cancer Centers, National Cancer Institute and has served as an ad hoc reviewer for several NIH study sections. He was a member of the Board of the Federation of American Societies for Experimental Biology. He is a past president of the International Society of Experimental Hematology and past member of the Council of the American Society for Clinical Investigation (ASCI). Dr. Williams has received numerous awards for his research, including the E. Mead Johnson Award for Research in Pediatrics from the Society for Pediatric Research (SPR), the William Dameshek Award from the American Society of Hematology, and the Samuel Rosenthal Prize for Excellence in Pediatrics by the Association of Medical School Pediatric Department Chairmen (AMSPDC). Dr. Williams received the Frank Oski Award at the 2006 meeting of the American Society of Pediatric Hematology/Oncology and the Donald Metcalf Award at the 2006 meeting of the International Society of Experimental Hematology. In 2002, he was elected to the Institute of Medicine of the National Academy of Sciences. In 2007, he was elected as a Fellow of the American Association for the Advancement of Science (AAAS).
Dr. Williams participates in the care of children with genetic and other hematologic diseases of the blood. He served as the inaugural Co-director of the Cincinnati Fanconi Anemia Comprehensive Care Center at Cincinnati Childrens Hospital Medical Center. He currently attends on the Hematology service at Childrens Hospital Boston. He co-directs the Fanconi Anemia and Bone Marrow Failure multidisciplinary clinic at Children's Hospital Boston.
Dr. Williams has served as the Director, Hematology/Oncology Fellowship Training Program at CCHMC from 2002-2007. He is currently a member of the Executive Committee of the Dana Farber / Harvard Cancer Institute and Editor-in-Chief of Molecular Therapy. He is a member of the NIH Recombinant DNA Advisory Committee (RAC) and has been active in development and implementation of multiple human gene therapy trials.
Dr. Williams leads the Translational Research Program at CHB. The purpose of this initiative is to build an infrastructure to facilitate more rapid migration of discovery research into pediatric clinical trials.
Medical School
Medicine, Indiana University School of Medicine, Indianapolis, IN
(1979)
Internship
Pediatrics, Cincinnati's Children's Hospital Medical Center, Cincinnati, OH
(1980)
Residency
Pediatrics, Cincinnati's Children's Hospital Medical Center, Cincinnati, OH
(1982)
Fellowship
Hematology/Oncology, Children's Hospital Boston/Dana-Farber Cancer Institute, Boston, MA
(1985)
Professional Organizations
Sam Dalinsky Resident Award, Children's Hospital Medical Center
Reticuloendothelial Society
American Society of Pediatric Hematology/Oncology
American Association for Cancer Research
American Association for the Advancement of Science
Federation of American Societies for Experimental Biology (FASEB)
American Pediatric Society
Cincinnati Pediatric Society
American Society of Human Genetics
American Society of Hematology
International Society for Experimental Hematology
Midwest Society for Pediatric Research
American Society for Blood and Marrow Transplantation
American Society of Gene Therapy
American Society for Clinical Investigation
Glenn W. Irwin Research Scholar Award, Indiana University and Purdue University
Awards
M.D. with Distinction, Indiana University School of Medicine
Alpha Omega Alpha, National Honorary in Medicine
Magna Cum Laude, Indiana State University
American Society for Clinical Investigation
NIH Young Investigator Award
Basil O'Connor Starter Research Award of the National Foundation March of Dimes
American Society for Blood and Marrow Transplantation, Councilor
Otis R. Bowen, M.D. Distinguished Leadership Award, Indiana University School of Medicine Dean's Council
E. Mead Johnson Award for Research in Pediatrics
International Society for Experimental Hematology,
Election to Hall of Honor, Cincinnati Childrens Hospital Medical Center
Association of American Physicians
Fellow, American Association for the Advancement of Science
Donald Metcalf Award, International Society of Experimental Hematology
Frank Oski Award and Memorial Lecture, American Society Pediatric Hematology/Oncology
American Pediatric Society
28th Annual Alan Cooper Smith Professor, The Johns Hopkins University
Member, Institute of Medicine, National Academy of Sciences
Samuel Rosenthal Prize for Excellence in Pediatrics, Association of Medical School Pediatric Department Chairman
Burroughs Welcome Fund (BWF) Visiting Professorship in the Basic Medical Sciences, The Brody School of Medicine, East Carolina University
William Dameshek Award, American Society of Hematology
Association of American Physicians
World of Difference Award, Indiana Health Industry Forum
Secretary/Treasurer, American Society of Clinical Investigation
President, International Society of Experimental Hematology
Vice President and President-elect, International Society of Experimental Hematology
Distinguished Alumni of 1996, Indiana State University
Keynote Speaker, Indiana University School of Medicine, Annual Scientific Session
American Society for Blood and Marrow Transplantation, Chair-Elect, Scientific Subcommittee on Hematopoiesis
Patents
DNA Encoding a Mammalian Cytokine, Interleukin-11
Serial Number 5/215,895
, Page: 1993
Mammalien Cytokine, IL-11
Serial Number 5/371/193
Issue: *Dr. Steve Paul, listed as an inventor, was post-doctoral fellow under Dr. David A. Williams supervision. Dr. Williams receives milestones and royalties from patents.
Method of Enhancing the Growth of Gut Epithelial Cells by Administration of a Cytokine Such as Interleukin 11
Methods for Enhanced Retroviral-Mediated Gene Transfer
Serial Number 8/218,355
DNA Sequences Encoding Fusions of DNA Repair Proteins and Uses Thereof
Serial Number 8/957,302
, 1999
Enhanced virus-mediated DNA transfer
Serial Number 6/033,907
, 2000
Methods for Enhanced Virus-Mediated DNA Transfer using Molecules with Virus-and Cell-Binding Domains
US Patent: 6, 670, 177 (Signed December 30, 2003)
Serial Number, 09/043,981
Publications
Gu Y, Chae H, Siefring JE, Jasti AC, Hildeman DA, Williams DA
RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development
, 2006
Nature Immunology
Thomas EK, Harris CE, Druker BJ, Zheng Y, Cancelas JA, Williams DA
Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR/ABL-induced myeloproliferative disease.
, 2007
Cancer Cell
Gu Y*◊ , Filippi MD*, Cancelas JA, Siefring JE, Williams EP, Jasti AC, Harris CE, Lee AW, Prabhakar R, Atkinson SJ, Kwiatkowski DJ, Williams DA:
Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases.
, 2003. *These authors contributed equally to this work; ◊ See Highlights, Nature Reviews 3, 925, 2003
Science
Milsom M, Schiedlmeier B, Bailey J, MiOk K, Li D, Jansen M, Ali A, Kirby M, Baum C, Fairbairn L and Williams DA:
Ectopic HOXB4 overcomes the inhibitory effect of tumor necrosis factor- α on Fanconi anemia hematopoietic stem and progenitor cells
, 2009
Blood
Muller L, Milsom MD and Williams DA
Rapid lentiviral transduction preserves engraftment potential of Fanca-/- hematopoietic stem cells.
, 2008
Molecular Therapy
Milsom MD, Jerabek-Willemsen M, Harris CE, Schambach A, Broun E, Bailey J, Jansen M, Schleimer D, Nattamai K, Wilhelm J, Watson A, Geiger H, Margison GP, Moritz T, Baum C, Thomale J and Williams DA
Reciprocal relationship between very high O6-methylguanine-DNA methltransferase P140K expression level and chemoprotection/selection of stem cells.
, 2008
Cancer Research
Dr. Williams major research interests are in the study of blood stem cell biology, blood formation, leukemia and the treatment of genetic blood diseases using gene therapy. He has published over 250 peer-reviewed manuscripts and textbook chapters. He was an investigator of the HHMI for 16 years. He has been continuously funded by the NIH since 1986. His laboratory co-discovered and cloned Interleukin-11 (Neumega TM) and carried out developmental studies that assisted in obtaining FDA approval of this drug. His laboratory also described and patented the use of fibronectin in retrovirus-mediated gene transfer, now nearly universally used (as Retronectin TM) in clinical gene therapy trials and basic research utilizing gene transfer. His most recent focus has been on exploring the role of Rho GTPases in hematopoietic stem cell biology. He and Dr. Yi Zheng have developed a new small molecule inhibitor of Rac GTPases that is being investigated collaboratively in cancer therapies. Thus, work in the Williams laboratory has led to multiple patents and product licenses for new therapies in human diseases. He also leads several gene therapy trials in immunodeficiency and neurologic disease.