Alagille Syndrome

What is Alagille syndrome?

The syndrome is usually diagnosed during infancy or early childhood. Alagille syndrome causes progressive destruction of the bile ducts. Over time, people with Alagille syndrome can develop liver disease.

Alagille syndrome often affects other major organs in the body, including the heart, eyes, kidneys and spine. Children with Alagille syndrome tend to have unique facial characteristics: a pointy chin, broad brow and widely spaced eyes.

About one in every 30,000 children is born with Alagille syndrome. It affects boys and girls and people of all races at equal rates.

How we care for Alagille syndrome

The Center for Childhood Liver Disease at Boston Children’s Hospital specializes in helping infants, children, adolescents and young adults who have a wide variety of liver, gallbladder and bile duct disorders (otherwise known as hepatobiliary). Doctors refer children with liver disease to this program at Boston Children’s Hospital from all over the world.