MEDICAL SERVICES

EDUCATION

Medical School

  • Dalhousie University , 2008 , Halifax , Nova Scotia, Canada

Residency

  • University of Manitoba , 2012 , Winnipeg , Manitoba, Canada

Fellowship

  • Boston Children's Hospital , 2016 , Boston , MA

PROFESSIONAL HISTORY

Dr Silvester completed her PhD in Biology at the University of Cambridge, Cambridge, England, prior to studying medicine at Dalhousie University in Halifax, Nova Scotia, Canada. She completed her residency at the University of Manitoba in Winnipeg, Canada and her Fellowship in Gastroenterology, Hepatology and Nutrition at Boston Children’s Hospital. Dr Silvester continues to work as a general pediatrician in remote regions of Northern Canada as well as at Boston Children’s Hospital. Her research interests include the diagnosis and management of celiac disease.


CERTIFICATIONS

  • American Board of Pediatrics, General Pediatrics
  • American Board of Pediatrics, Pediatric Gastroenterology

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Palmer NP, Silvester JA, Lee JJ, Beam AL, Fried I, Valtchinov VI, Rahimov F, Kong SW, Ghodoussipour S, Hood HC, Bousvaros A, Grand RJ, Kunkel LM, Kohane IS. Concordance between gene expression in peripheral whole blood and colonic tissue in children with inflammatory bowel disease. PLoS One. 2019; 14(10):e0222952. View abstract
  2. Weisbrod VM, Silvester JA, Raber C, McMahon J, Coburn SS, Kerzner B. Preparation of Gluten-Free Foods Alongside Gluten-Containing Food May Not Always Be as Risky for Celiac Patients as Diet Guides Suggest. Gastroenterology. 2019 Sep 24. View abstract
  3. Singh P, Singh A, Silvester JA, Sachdeva V, Chen X, Xu H, Leffler DA, Ahuja V, Duerksen DR, Kelly CP, Makharia GK. Inter- and Intra-assay Variation in the Diagnostic Performance of Assays for Anti-tissue Transglutaminase in 2 Populations. Clin Gastroenterol Hepatol. 2019 Sep 20. View abstract
  4. Therrien A, Kelly CP, Silvester JA. Celiac Disease: Extraintestinal Manifestations and Associated Conditions. J Clin Gastroenterol. 2019 Sep 10. View abstract
  5. Mataya L, Silvester J, Jericho H. Can We Ignore the Utility of Deamidated Gliadin Peptide in the Diagnosis of Celiac Disease in Children? J Pediatr Gastroenterol Nutr. 2019 Jul; 69(1):e23. View abstract
  6. Comino I, Segura V, Ortigosa L, Espín B, Castillejo G, Garrote JA, Sierra C, Millán A, Ribes-Koninckx C, Román E, Rodríguez-Herrera A, Díaz J, Silvester JA, Cebolla Á, Sousa C. Prospective longitudinal study: use of faecal gluten immunogenic peptides to monitor children diagnosed with coeliac disease during transition to a gluten-free diet. Aliment Pharmacol Ther. 2019 Jun; 49(12):1484-1492. View abstract
  7. Therrien A, Silvester JA, Leffler DA, Kelly CP. Efficacy of Enteric-Release Oral Budesonide in Treatment of Acute Reactions to Gluten in Patients With Celiac Disease. Clin Gastroenterol Hepatol. 2019 Mar 21. View abstract
  8. Clerx EM, Silvester J, Leffler D, DeGroote M, Fishman LN. Sequence of acquisition of self-management skills to follow a gluten-free diet by adults with celiac disease. Dig Liver Dis. 2019 08; 51(8):1096-1100. View abstract
  9. Silvester JA, Faucher EA, McCarty CE, Kalansky A, Hintze ZJ, Mitchell PD, Goldsmith JD, Weir DC, Leichtner AM. Red Spot Lesions in the Duodenal Bulb Are a Highly Specific Endoscopic Sign of Celiac Disease: A Prospective Study. J Pediatr Gastroenterol Nutr. 2019 02; 68(2):251-255. View abstract
  10. Singh P, Silvester J, Chen X, Xu H, Sawhney V, Rangan V, Iturrino J, Nee J, Duerksen DR, Lembo A. Serum zonulin is elevated in IBS and correlates with stool frequency in IBS-D. United European Gastroenterol J. 2019 06; 7(5):709-715. View abstract
  11. Blansky BA, Hintze ZJ, Alhassan E, Leichtner AM, Weir DC, Silvester JA. Lack of Follow-up of Pediatric Patients With Celiac Disease. Clin Gastroenterol Hepatol. 2019 Nov; 17(12):2603-2604. View abstract
  12. Singh P, Silvester JA, Leffler D. (Outcome) Measure for (Intervention) Measures: A Guide to Choosing the Appropriate Noninvasive Clinical Outcome Measure for Intervention Studies in Celiac Disease. Gastroenterol Clin North Am. 2019 03; 48(1):85-99. View abstract
  13. Silvester JA, Graff LA, Rigaux L, Bernstein CN, Leffler DA, Kelly CP, Walker JR, Duerksen DR. Symptoms of Functional Intestinal Disorders Are Common in Patients with Celiac Disease Following Transition to a Gluten-Free Diet. Dig Dis Sci. 2017 09; 62(9):2449-2454. View abstract
  14. Silvester JA, Kurada S, Szwajcer A, Kelly CP, Leffler DA, Duerksen DR. Tests for Serum Transglutaminase and Endomysial Antibodies Do Not Detect Most Patients With Celiac Disease and Persistent Villous Atrophy on Gluten-free Diets: a Meta-analysis. Gastroenterology. 2017 09; 153(3):689-701.e1. View abstract
  15. Leonard MM, Weir DC, DeGroote M, Mitchell PD, Singh P, Silvester JA, Leichtner AM, Fasano A. Value of IgA tTG in Predicting Mucosal Recovery in Children With Celiac Disease on a Gluten-Free Diet. J Pediatr Gastroenterol Nutr. 2017 02; 64(2):286-291. View abstract
  16. Silvester JA, Leffler DA. Is Autoimmunity Infectious? The Effect of Gastrointestinal Viral Infections and Vaccination on Risk of Celiac Disease Autoimmunity. Clin Gastroenterol Hepatol. 2017 05; 15(5):703-705. View abstract
  17. Silvester JA, Kalkat H, Graff LA, Walker JR, Singh H, Duerksen DR. Information seeking and anxiety among colonoscopy-naïve adults: Direct-to-colonoscopy vs traditional consult-first pathways. World J Gastrointest Endosc. 2016 Nov 16; 8(19):701-708. View abstract
  18. Silvester JA, Graff LA, Rigaux L, Walker JR, Duerksen DR. Symptomatic suspected gluten exposure is common among patients with coeliac disease on a gluten-free diet. Aliment Pharmacol Ther. 2016 09; 44(6):612-9. View abstract
  19. Silvester JA, Weiten D, Graff LA, Walker JR, Duerksen DR. Is it gluten-free? Relationship between self-reported gluten-free diet adherence and knowledge of gluten content of foods. Nutrition. 2016 Jul-Aug; 32(7-8):777-83. View abstract
  20. Silvester JA, Kelly CP. The Potential for Treatment of Potential Celiac Disease. Clin Gastroenterol Hepatol. 2016 May; 14(5):694-5. View abstract
  21. Silvester JA, Leffler DA. Recent Advances in Celiac Disease from TTG to Gluten in Pee. Clin Transl Gastroenterol. 2015 Nov 12; 6:e125. View abstract
  22. Silvester JA, Weiten D, Graff LA, Walker JR, Duerksen DR. Living gluten-free: adherence, knowledge, lifestyle adaptations and feelings towards a gluten-free diet. J Hum Nutr Diet. 2016 Jun; 29(3):374-82. View abstract
  23. Silvester J, Duerksen D. Five things to know about...celiac disease. CMAJ. 2013 Jan 08; 185(1):60. View abstract
  24. Silvester JA, Rashid M. Long-term management of patients with celiac disease: current practices of gastroenterologists in Canada. Can J Gastroenterol. 2010 Aug; 24(8):499-509. View abstract
  25. Silvester JA, Rashid M. Long-term follow-up of individuals with celiac disease: an evaluation of current practice guidelines. Can J Gastroenterol. 2007 Sep; 21(9):557-64. View abstract
  26. Dickson VK, Silvester JA, Fearnley IM, Leslie AG, Walker JE. On the structure of the stator of the mitochondrial ATP synthase. EMBO J. 2006 Jun 21; 25(12):2911-8. View abstract
  27. Silvester JA, Dickson VK, Runswick MJ, Leslie AG, Walker JE. The expression, purification, crystallization and preliminary X-ray analysis of a subcomplex of the peripheral stalk of ATP synthase from bovine mitochondria. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jun 01; 62(Pt 6):530-3. View abstract
  28. Carbajo RJ, Silvester JA, Runswick MJ, Walker JE, Neuhaus D. Solution structure of subunit F(6) from the peripheral stalk region of ATP synthase from bovine heart mitochondria. J Mol Biol. 2004 Sep 10; 342(2):593-603. View abstract
  29. Docherty JC, Kuzio B, Silvester JA, Bowes J, Thiemermann C. An inhibitor of poly (ADP-ribose) synthetase activity reduces contractile dysfunction and preserves high energy phosphate levels during reperfusion of the ischaemic rat heart. Br J Pharmacol. 1999 Jul; 127(6):1518-24. View abstract