Research

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Funding | Pilot Grants

Letter of Intent - due February 1, 2017
Full Application - due April 12, 2017

All materials should be submitted to the TRP.

Download the application.

Purpose of grants

Proposed research projects must be related to the goals of the Translational Research Program (TRP). In brief, the TRP has been established to encourage the development of interactions between basic scientists and clinicians to foster the development of non-clinical and clinical investigations for children with serious diseases. Thus, studies which include the participation of both clinicians and basic scientists are preferred. The ultimate goal of the TRP is to facilitate clinical trials that utilize the findings generated through this funding mechanism.

Types of grants available

  • New research proposals: These grants are for one year of support. The maximum allowable budget (di-rect costs) is $100,000. The number of awardees will be determined by the quality of the proposals, the total amounts of the requested budgets of sufficiently meritorious proposals, and available funds. It is anticipated that 6-8 awards will be made in the $50,000-$100,000 range.
  • Competing renewal applications: For those projects previously supported by the TRP, a second year of support may be sought. These applications will be reviewed in the same manner as new applications. Applications must include a Progress to Date section, and must convincingly justify the need for more support.

Eligibility

Applications will be accepted from all faculty of Boston Children's Hospital, including nursing, health outcomes and other health care faculty with advanced degrees (MD, PhD, MD, PhD, or equivalent). Clusters of investigators spanning disciplines and programs made up of basic and clinical faculty are strongly encouraged. Fellows are not eligible.

Process

The initial application will consist of a 2 page Letter of Intent (LOI). The LOI will be screened to examine if the proposed research project supports the goals of the TRP. The screening process will be performed by a multidisciplinary committee representing established researchers at CHB and chaired by the Director of the Translational Research Program. Following the initial screening, an invitation will be sent to selected investigators to submit the full application. Funding of selected proposals will commence on July 1st.

Letter of intent

For research proposals, the LOI consists of the application face page (see #1 below in "Composition of Research Proposal") and 1-2 pages of the hypothesis and specific aims page (see #9 below in "Composition of Research Proposal"). The aims should include a brief description of the research design and methods. All LOI applications must be submitted to TRP@childrens.harvard.edu. An email confirmation of receipt will be returned to the applicant.

Signatures

The signature of the primary investigator (and co-investigator) is required in the Letter of Intent initial application. Additionally, the signature of the primary investigator's Department Chairman is required and indicates his/her commitment to providing 30% match of direct costs (plus associated applicable overhead) should the proposal be awarded.

Letter of support

Full applications must include a letter of support from the primary applicant's chairperson. Included in the letter of support must be a statement regarding the priority of the research proposal for the division, particularly as it relates to patient resources.

Required format

Applications must also be submitted electronically (except letter of support, unless it is also available electronically). Send a PDF file of assembled proposal to TRP@childrens.harvard.edu.

Full proposals, if invited, must be submitted in single spaced text, one-half inch margins, and no smaller than an 11-point font. Arial or Helvetica typeface is preferred. The primary applicant's name must appear in the upper right hand corner of each page. Proposal text must be limited to five pages (including fig-ures but excluding references). Standard PHS 398 forms for budget, biosketch, other support, and re-sources may be used and may be submitted as separate files.

Composition of research proposal

  • Face page (check all appropriate COMS, animal, IRB, or Radiation Safety approvals or indicate pending if submitted)
  • Abstracts (Scientific and Lay)
  • Tables of Contents
  • Detailed Budget (1 year; use PHS 398 form provided)
  • Budget Justification
  • Biosketch(es) (Include PI and co-investigators; use PHS 398 form)
  • Other support (PHS 398 form)
  • Resources (PHS 398 form)
  • Hypothesis and Specific Aims
  • Background and Significance
  • Preliminary Results or, if 2nd year renewal, Progress Report
  • Research Design and Methods
  • Statement of how proposal supports TRP mission
  • *Statement of Commercialization Potential (include any issues of intellectual property).
  • Literature cited
  • Letter of support from Division chairperson
  • *Letters of support from collaborators or consultants

*optional

Pilot Awardees

2016

Suneet Agarwal - Hematology/Oncology
Poly(A) polymerase inhibitors for the treatment of telomere diseases

Daniel Bauer - Hematology/Oncology
Biology studies of hematopoietic stem and progenitor cells mobilized by plerixafor from patients with sickle cell disease.

Roberto Chiarle - Pathology
Development of CART T cells against the ALK oncogene

Brian Crompton - Hematology/Oncology
Development of a Circulating Tumor DNA Assay for Ewing Sarcomas

Xi He - Neurology
A Therapeutic Strategy for Atopic Dermatitis by Targeting the WNT Pathway

Juan Melero-Martin - Cardiac Surgery
Human trabecular bone endothelial cells regulate osteoregeneration

Sung-Yun Pai - Hematology/Oncology
Development of a gene therapy model for DOCK8 deficiency

Rachel Rosen - GI/Nutrition
Microbiome and Metabolomic Changes in Exhaled Breath Condensate as a Biomarker of Extraesophageal Reflux Disease

2015

Frank Pigula - Cardiac Surgery
A Biometric Direc Cardiac Compression Device

Yana Pikman - Oncology
Cdk4/6 inhibition for T-cell Acute Lymphoblastic Leukemia

Rima Rachid - Immunology
The role of Fecal Microbiota Transplant in causing sustained unresponsiveness after peanut oral immunotherapy in peanut allergy patients

Alex Rotenberg - Neurology
Measuring oxidative stress and its impact on cortical inhibition by MRS

Benoit Scherrer - Radiology
Toward in vivo neuroimaging biomarkers of concussion: evalutaion with a mousel model of repetitive mild traumatic brain injury (rmTBI)

2014

Michela Fagiolini -Neurology
Predicting Regression and Response to Treatment in Rett Syndrome

Kristin Moffitt - Infectious Disease
Identification of candidate Staphylococcus aureus vaccine antigens by RNA expression profile analysis of human abscesses

Frank Pigula - Cardiac Surgery
A Biometric Direc Cardiac Compression Device

Shenandoah Robinson - Neurosurgery
Serum Biomarkers Predict Need for Erythropoietin Treatment in Preterm Infants

Hanno Steen - Pathology
Urine Proteomics to Identify Biomarkers for Tuberculosis

2013

Joyce Bischoff - Vascular Biology Program
Cellular and Molecular Basis of Lymphatic Malformations

Talal Chatila - Immunology
Regulatory T Cell Bio-Markers of Food Allergy Outcomes

Roberto Chiarle - Pathology
ALK Tumor Vaccine in Neuroblastoma

Steven Colan - Cardiology
Novel Cardiac Biomarkers and Tissue Doppler Imaging for Rejection Surveillance after Pediatric Heart Transplantation

Pedro del Nido - Cardiac Surgery
Novel Strategies for Intracardiac Septal Defect Closure

Michela Fagiolini - Neurology
Pre-Clinical and Clinical Testing of NMDAr Antagonist Treatment in Rett Syndrome

Medhi Hedjazi Moghari - Cardiology
Accelerated 3D-SSFP Magnetic Resonance Imaging for Guiding Congenital Heart Disease Management

2012

William Bosl - Endocrinology
Biomarkers for Early Identification of Children with Epileptic Encephalopathies

Larry Benowitz - Neurosurgery
The Effects of Inosine in Promoting Recovery after Spinal Cord Injury

Pedro del Nido - Cardiovascular Surgery
A Novel Light-Activated Adhesive for Pediatric Cardiovascular Applications

Paolo Fiorina - Nephrology
Role of B7.1 in Diabetic Nephropathy: Establishing the CTLA4-lg Clinical Trial

Xi He - Neurology
A Novel Strategy for Turning off β-catenin Oncogenic Signaling in Cancer

Matthew Heeney - Hematology/Oncology
Pilot Trial of Glycine Supplementation in Autosomal Recessive Congenital Sideroblastic Anemia Due to Mutations in SLC25A38

Richard Lee - Urology
Early Validation of Urinary Biomarkers of Renal Obstruction

Richard Malley - Orthopedics
Development of a Multiple Antigen Presentation System (MAPS) Pneumococcal Vaccine

Martha Murray - Orthopedics
Regeneration of the Anterior Cruciate Ligament after Rupture

Hans Oettgen - Immunology
Safe Food Allergy Desensitization using IgE Receptor Signaling Inhibitors

Simon Warfield - Radiology
Diffusion-Weighted MRI for the Assessment of Disease Activity and Progression in Pediatric Chron’s Disease

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2011

Paolo Fiorina - Medicine
Role of B7.1 in Diabetic Nephropathy

Rani George - Oncology
Validation of a Genetically Engineered Mouse Model of Neuroblastoma Drive by Mutated AIK and MYCN

Takao Hensch - Neurology
Recovery from Amblyopia with Cholinesterase Inhibitors

Joel Hirschhorn - Endocrinology
New Genetic Classes of Idiopathic Short Stature Defined by Sequence and Copy Number Variants

Robert Husson - Infectious Disease
Stress-Potential Screens to Identify Novel Inhibitors of M. Tuberculosis

Omar Khwaja - Neurology
Pilot Trial of Mecasermin (rDNA) Injection to Treat Rett Syndrome

Hannah Kinney - Pathology
Potential Clinical Biomarkers of SIDS

Brian Snyder - Orthopaedics
Development of Contrast Enhanced Quantitative CT as Clinical Tool for Arthritis

2010

Xi He - Neurology
Chemical inhibition of a novel Wnt modulator for osteoporosis therapeutics

Jordan Kreidberg - Nephrology
c-Met inhibitor treatment of Polycystic Kidney Disease

David Ludwig - Endocrinology
Effects of a food preservative on glucose Homeostasis

Alexander Rotenberg - Neurology
Closed-loop adjustment of transcranial direct current stimulation (tDCS) in of status epilepticus

Dale Umetsu - Immunology
Renewal: A novel therapy for severe food allergy by rapid and safe induction of oral tolerance

Dennis Wall - Medicine/Informatics
Deciphering autism through cross-disease system biology

Gerhard Wolf - Anesthesia
Reducing ventilator-associated lung injury through non-invasive bedside imaging

2009

Joyce Bischoff - Vascular Biology
A stem/progenitor cell that recapitulates infantile hemangoma

Wayne Lencer - Gastroenterology
Novel platform for mucosal protein drug/vaccine delivery and increased half-life

Luigi Notarangelo - Immunology
Use of engineered meganucleases to correct RAG1 deficiency in humans

Alexander Rotenberg - Neurology
Treatment of Status Epilepticus by Transcranial Direct Current Stimulation

Janet Soul - Neurology
Pilot Trial of Bumetanide to Treat Neonatal Seizures

Hanno Steen - Pathology
Urine proteomics of Kawasaki disease and pediatric vasculitis

Dale Umetsu - Immunology
A Novel Therapy for Severe Food Allergy by Rapid and Safe Induction of Oral Tolerance

2008

Joyce Bischoff - Vascular Biology Program
Cellular and Molecular Basis of Lymphatic Malformations

Talal Chatila - Immunology
Regulatory T Cell Bio-Markers of Food Allergy Outcomes

Roberto Chiarle - Pathology
ALK Tumor Vaccine in Neuroblastoma

Steven Colan - Cardiology
Novel Cardiac Biomarkers and Tissue Doppler Imaging for Rejection Surveillance after Pediatric Heart Transplantation

Pedro del Nido - Cardiac Surgery
Novel Strategies for Intracardiac Septal Defect Closure

Michela Fagiolini - Neurology
Pre-Clinical and Clinical Testing of NMDAr Antagonist Treatment in Rett Syndrome

Medhi Hedjazi Moghari - Cardiology
Accelerated 3D-SSFP Magnetic Resonance Imaging for Guiding Congenital Heart Disease Management 

2007

Scott Armstrong - Hematology/Oncology
Reversal of Glucocorticoid Resistance in Acute Lymphoblastic Leukemia

Joyce Bischoff - Vascular Biology Program
A stem/progenitor cell that recapitulates infantile hemangoma

Gabriel Corfas - Neurology
GDNF receptor agonists to treat peripheral neuropathies

Robert Husson - Infectious Diseases
Proteome-wide screen for M. tuberculosis antigens

Richard Malley - Infectious Diseases
A transcutaneous vaccine to prevent pneumococcal colonization and disease

Benjamin Matthews - Critical Care
Microparticles with TRPV4 inhibitor for lung protection

Umut Ozcan -Endocrinology
Role of ER Stress in Development of Leptin Resistance

Mark Puder - Surgery
The essentiality of archidonic acid (AA), docosahexaaenoic acid (DHA)

Leslie Silberstein - Blood Bank/Transfusion Medicine
Novel Approaches in Targeting Pediatric B-ALL

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Early Validation of Urinary Biomarkers of Renal Obstruction

Early Validation of Urinary Biomarkers of Renal Obstruction

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