The George Laboratory seeks to:
Identify molecular targets that can be translated into novel therapies in the pediatric solid tumor neuroblastoma
Unravel the genetic perturbations that occur during development of the sympathetic nervous system and underlie neuroblastoma initiation and progression. Following our discovery of activating, inhibitor-sensitive somatic mutations in the ALK tyrosine kinase in neuroblastoma (Nature, 2008), we are investigating mechanisms of ALK activation and regulation, as well as strategies to inhibit ALK that can be employed therapeutically.
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