The Zanoni lab seeks to understand the events that initiate protective immunity in response to infection and tissue injury, or that drive the development of immune-mediated diseases; to this end, we scrutinize innate immune cell biology, with a primary focus on unraveling the PRR signaling pathways that are triggered by PAMP and DAMP encounter. The organizing principles that govern PRR signaling are largely unknown. We believe that elucidation of these principles will answer fundamental questions about the pathophysiology of the inflammatory process. Our current strategy for achieving these goals is to integrate findings derived from a combination of in vitro signaling studies and in vivo murine models, apply this information to refine our hypotheses, and create models that can explain - and possibly predict - the pathophysiology of inflammation in humans.
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