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Research Fellowship Opportunities

Siatik Bioinformatics Consultant

Bioinformatics Consultant
Company: Siatik
Location: Boston, MA
Type: Part Time Consultant

Siatik aims to recruit a masters level, doctoral, or postdoctoral bioinformatician to provide expertise as we develop a genomic analysis platform that will serve research scientists. A strong desire to be part of an exciting startup and an entrepreneurial spirit is required. The successful candidate will play a key role in design and development of the platform by providing insight into existing computational programs and pipelines that are used to analyze genomic data in various biological disciplines (precision medicine, cancer research, mendelian disorders, microbiome…). Importantly, we are seeking an individual who is driven to move the scientific community forward by giving researchers the tools they need to analyze complex data quickly and efficiently. Our bioinformatician will become a member of our professional team composed of platform developers and research scientists as well as collaborators through our partnerships with Google and Dell. In addition, the individual in this position will have an opportunity to develop a novel idea into a global enterprise.

Responsibilities:
Serve as the primary bioinformatician within the startup and provide support to other members of the Siatik team and function as the content expert in computational tools and paradigms used to analyze genomic data within the company.
• Collaborate with our platform developers and research physicians in the development of the analysis platform until the product is market ready.
• After the genomic analysis platform is introduced to the market, continue to provide insights on potential product improvements.
• Liaise with users and organizations engaged in data science and genomics.

Qualifications:
• A masters, doctorate or post-doctorate degree in bioinformatics or a closely related field (i.e. computational biology, computer science, etc.)
• Demonstrated experience in genomic analysis (whole exome, whole genome, RNAseq) with open source programs such as Galaxy.
• Proficiency with R and/or Python (preferred)
• Familiarity with practices related to collaborative and reproducible scientific work
• Willingness and ability to serve many roles as required within a startup environment.
• Strong oral and written communication skills
• Strong organizational and administrative skills
• Ability to work independently to identify and implement optimal solutions to diverse problems

Please contact Nathan Ali at nathan@siatik.com for any questions or to submit your CV and cover letter


Columbia University Medical Center, Postdoctoral Research Scientist

Seeking a highly motivated Postdoctoral Research Scientist with expertise in stem cell biology and
neuroscience to study molecular mechanisms of human obesity genes. This work will be done at
Columbia University (Naomi Berrie Diabetes Center) in direct collaboration with Drs. Rudolph Leibel,
Dieter Egli, Wendy Chung, and Vidhu Thaker; utilizing state-of-the-art human stem cell/iPSC technology,
CRISPR, in vitro differentiation, in vivo transplantation into mouse brain, single cell sequencing as well as
cell biology and biochemical approaches.

Preferred qualifications:
1. Experience and knowledge in human stem cell biology and neuroscience.
2. Ability to work independently and as part of a team.
3. Excellent written and oral communication skills in English.
4. Record of productive research.
5. Education: Ph.D. and/or M.D.

Position salary is competitive and will be based on qualifications.

Applicants should send curriculum vitae, statement of interest, and contact information for three
references to:Claudia A. Doege, M.D.
cad2114@cumc.columbia.edu 


Studying heart development, stem cell, cardiac regeneration and cardiovascular disease using state-of-the art technologies

We are actively seeking highly motivated young scientists to join our lab as postdoctoral fellows.

Our lab studies the molecular mechanisms of heart development, cardiac function and related diseases. Over the past several years, we focused on the functions of transcription factors and microRNAs and we have demonstrated their critical roles in heart development, contraction, remodeling and regeneration (Wang et al., Cell, 105: 851; Chen et al., Nature Genetics, 38:228; Huang et al., JCI, 125, 4122; Ding et al., Nature Genetics, 47:776). We are also studying the function of lncRNAs in the heart and skeletal muscle.

The postdoc candidates have the opportunity to work on exciting projects and state-of-the-art technologies. The Boston Children's Hospital and Harvard Medical School is the preeminent medical school in the country which offers a very rich and varied academic and cultural environment.

Please send your CV and three references to:

Da-Zhi Wang, PhD

Professor

Cardiovascular Research Division

Department of Cardiology

Boston Children's Hospital

Harvard Medical School

Enders 1262.1

320 Longwood Avenue

Boston, MA 02115

E-mail: dwang@enders.tch.harvard.edu

Phone: 617-919-4768

Fax: 617-731-0787

Homepage: http://wang.tchlab.org/


Postdoctoral position: Division of Infectious Diseases

An NIH-funded position is available for an exceptionally talented and motivated postdoctoral
fellow seeking to expand his or her knowledge of the host-intestinal microbe interaction by
investigating the influence of intestinal pathogens and commensals on host metabolism. 

The successful candidate will join a vibrant research team exploring the metabolic pathways of
intestinal bacteria, their impact on host metabolism, and the role of novel vaccine platforms.
He or she will have appointments both at Boston Children’s Hospital and Harvard
Medical School and will participate in the activities of the Infectious Diseases Division at
BCH and the Department of Microbiology and Immunobiology at Harvard Medical
School.

Recent graduates with a track-record of productivity and excellent references are encouraged to
apply. Candidates should send a statement of interest and future goals and a curriculum vitae
and should request three letters of reference to be sent directly from mentors familiar with their
scientific abilities to paula.watnick@childrens.harvard.edu.

To learn more about our areas of interest, please see:
Hang S, Purdy AE, Robins WP, Wang Z, Mandal M, Chang S, Mekalanos JJ, Watnick PI. The
acetate switch of an intestinal pathogen disrupts host insulin signaling and lipid metabolism. Cell Host Microbe. 2014 Nov 12;16(5):592-604.

Vanhove AS, Hang S, Vijayakumar V, Wong CAN, Asara JM, Watnick PI.Vibrio cholerae ensures function of host proteins required for virulence through consumption of luminal methionine sulfoxide, PLoS Pathogens, 2017.


Postdoctoral position: Genetics of Congenital Adrenal Hyperplasia in a Zebrafish Model

The Institute for Pediatric Urology Research Laboratory at Weill Cornell Medical College seeks an outstanding postdoctoral fellow for research seeking to further our understanding of the  genetics of Congenital Adrenal Hyperplasia (CAH), an autosomal recessive disease, resulting in inherited  enzymatic deficiencies in cortisol synthesis. The most common form of CAH is a deficiency in  CYP21A2 (21-hydroxylase ), accounting for over 90% of all cases. More than 100 unique mutations have been found in CAH. In Classic CAH, there is a general correlation between genotype and phenotype; however, the clinical manifestations of nonclassic disease are quite variable, suggesting that other factors (genetic, epigenetic or environmental) may affect the phenotypic expression. The current project will be focused on using the zebrafish model to study the complex genetics of CAH. 

The Division of Pediatric Urology at Weill Cornell has been designated a “Comprehensive  Center for Congenital Adrenal Hyperplasia” by the CARES Foundation. As such, we are the  premier clinical center in the US for surgical and medical management of CAH patients. The  studies described here will enhance our understanding of CAH and contribute to improved  patient care. These experiments will be done in collaboration with laboratories at Weill  Cornell that have expertise using zebrafish to model human disease.

Candidates should have a PhD or MD, with a background in molecular genetics.  Additional expertise in zebrafish biology or endocrinology is preferred, but not required. Responsibilities include  designing and conducting experiments, collecting and analyzing data, preparing and presenting research  findings at meetings, writing scientific manuscripts, and applying for fellowships/grants. The  successful candidate will be a highly motivated individual with an outstanding publication  record, excellent written/verbal English communication skills, strong organizational skills, and  the ability to work independently. 

Applicants should contact Dr. Diane Felsen  [dfelsen@med.cornell.edu]  and submit curriculum vitae, brief description of research interests and accomplishments including list of publications (published and “in preparation”) and contact information of 3 references all in a single PDF file.    EOE/Minorities/Females/Vet/Disabled


Research Lab Supervisor in the Department of Research-Biorepository

At Boston Children’s Hospital, success is measured in patients treated, parents comforted and teams taught. It’s in discoveries made, processes perfected, and technology advanced. In major medical breakthroughs and small acts of kindness. And in colleagues who have your back and patients who have your heart. As a teaching hospital of Harvard Medical School, our reach is global and our impact is profound. Join our acclaimed Biorepository Lab and discover how your talents can change lives. Yours included.

This Research Laboratory Supervisor will be responsible for:

  • Training and supervising staff, including providing continuing education.
  • Creating and maintaining laboratory documentation including standard operating procedures, equipment maintenance logs, specimen shipment receipts, etc.
  • Managing laboratory inventory and equipment, including validation and implementation of automation.
  • Monitoring laboratory services for accuracy, efficiency, and adherence to deadlines.
  • Working with management and staff to develop and implement quality assurance program and ensure compliance.
  • Providing knowledgeable and courteous customer support.
  • Leading continuous improvement, process optimization, development, and implementation projects for advancement and scale-up of services and throughput.
  • Ensuring compliance with governmental and hospital regulations.
To qualify, you must have:
  • A Bachelor's degree in Biology, Chemistry.
  • A minimum of 2 years of experience supervising staff in a clinical or research laboratory settings with demonstrated success in leading team members to reach goals and objectives.
  • A high degree of problem solving and decision making skills.
  • Detail-oriented with proficient organizational, writing, and record-keeping skills.
  • Efficient time management skills and the ability to multitask in a fast-paced environment with changing priorities.
  • The ability to meet high performance standards with regard to work quality and quantity.
The Biobank is a fast-paced facility experiencing rapid growth, requiring a Research Lab Supervisor who exhibits strong leadership, communication, organizational, and interpersonal skills, with an ability to analyze complex issues and make sound decisions in a timely manner. Candidate must respond to and lead change, adapting quickly to evolving circumstances, and communicate team goals, priorities, and issues effectively to staff and management.  This is a hands-on role responsible for the day-to-day supervision and oversight of the laboratory operations and services.

Boston Children’s Hospital offers competitive compensation and unmatched benefits, affordable health, vision and dental insurance, generous levels of time off, 403(b) Retirement Savings plan, Pension, Tuition Reimbursement, cell phone plan discounts and discounted rates on T-passes (50% off). Discover your best.
 
Boston Children’s Hospital is an Equal Opportunity / Affirmative Action Employer. Qualified applicants will receive consideration for employment without regard to their race, color, religion, national origin, sex, sexual orientation, gender identity, protected veteran status or disability.

To apply: Please send resume and cover letter to Tram Tran, Tram.Tran@childrens.harvard.edu 

Postdoc in Type 2 diabetes, Obesity, and Metabolism

A postdoctoral fellow position is available in the lab of Dr. Sang Park at Boston Children’s Hospital, Harvard Medical School. We are located in the center of the Longwood medical area (3 Blackfan Circle, Boston). The fields of our interest are Obesity, Type 2 diabetes, and ER stress.

The goal of this project is to understand the molecular mechanisms by which insulin resistance and type 2 diabetes develop in obesity.

The project involves cell culture and mouse experiments.

Background in Molecular biology (western blot, DNA/RNA works) is a must requirement. Please visit our website at parklab.info for more information.

Please send your CV and 3 references’ contact information to: sangpark2014@gmail.com


Science Program Manager, Boston Children's Hospital

The Scientific Program Manager works as part of a dynamic professional team that reports to the Director of the Translational Neuroscience Center (TNC) at Boston Children’s Hospital. The specific duties of the Scientific Program Manager are to engage with leading neuroscience faculty and other TNC staff in the development of both basic science and clinical research projects and to oversee the process of generating proposals from concept development, to identification of appropriate federal and nonfederal funding sources, to writing and editing proposals. Additional responsibilities include developing and maintaining public information on the TNC (e.g. written materials, PowerPoint presentations, and web content), coordinating research symposia in collaboration with other TNC staff, and managing grant reports.

Responsibilities:
• Assist with scientific grant and proposal development and writing for both neuroscience laboratory initiatives and clinical research on neurodevelopmental disorders
• Solicit and administer peer review of requests submitted to the TNC for funding of pilot projects in translational neuroscience
• Work with TNC leadership and vendors to develop and update marketing materials for the TNC including web sites, newsletters, brochures, and slide decks that describe scientific resources available through the TNC to academic, foundation, and industrial audiences.
• Develop donor materials including annual reports and timely progress reports to grant makers
• Lead the TNC staff and administrative team in planning scientific events such as scientific symposia, seminar series, and educational workshops.

Basic Qualifications:
MS required, preferably in neuroscience or related field. 7+ years relevant experience.

Additional Qualifications:
Ph.D preferred. 2-3 years of experience in planning, writing grants, or scientific communication. The candidate will provide documentation of demonstrated success in preparing successful government and private funding research grants. Strong communication skills, both written and oral. Strong computer skills including MS Office, particularly PowerPoint and Excel. Strong leadership skills with the ability to work collaboratively with multi-departmental and multi-institutional teams. Demonstrated ability to effectively set priorities, recognize and solve problems proactively, and provide keen attention to detail.

About the Translational Neuroscience Center:
The Translational Neuroscience Center (TNC) at Boston Children’s Hospital provides a unique environment for physicians and scientists dedicated to improving the lives of children with brain disorders through inter-disciplinary collaborations based on the latest scientific discoveries. Recent advances in neurobiology, cognitive neuroscience, genetics and genomics, imaging, stem cell biology, systems biology, and other fields have produced a flood of new information about the mechanisms underlying normal human development and how those mechanisms go awry in pediatric disorders. The TNC seeks to build on this knowledge to improve the diagnosis, treatment, and prevention of brain disorders that affect children.
The TNC was conceived and launched under the leadership of Scott Pomeroy, MD, PhD, Neurologist–in-Chief and CliffordWoolf, MB, BCh, PhD, Chair of the F.M. Kirby Neurobiology Center to create and extend a collaborative framework for supporting exceptional translational neuroscience across all departments at Boston Children’s Hospital. TNC Director Mustafa Sahin, MD, PhD, oversees a growing portfolio of programs designed to accelerate translational research through rapid development of new treatments ranging from target identification to Phase 2 proof of concept clinical trials. The TNC is guided by a distinguished Executive Committee comprised of senior hospital leadership across the neuroscience disciplines.

Please contact Kira A. Dies, ScM, CGC at kira.dies@childrens.harvard.edu for any questions or to submit your CV and cover letter.
Boston Children’s Hospital is an equal opportunity/affirmative action employers with strong institutional commitments to diversity in their faculty. Women and minority candidates are particularly encouraged to apply.



Postdoc in the Division of Infectious Diseases/Department of Medicine at Boston Children’s Hospital

Job description

The Levy Laboratory is the focal point of the Precision Vaccines Program at Boston Children’s Hospital/Harvard Medical School. The Program employs cutting edge technologies to understand age-specific features of immune responses to inform development of vaccines tailored for optimal safety and immunogenicity towards distinct populations. Due to distinct immunity, most infection-induced death occurs at the extremes of life motivating development of improved vaccines that are safe and effective in the young and old. We seek a skilled and motivated post-doctoral scientist with background in Immunology (experience in T and B lymphocyte studies a plus), Vaccinology, and/or Systems Biology and Bioinformatics to lead projects employing systems biology to characterize age-specific vaccine responses and development of novel adjuvanted vaccines. The project will employ recent knowledge in the areas of innate immune pathways (TLRs/inflammasome) and nanoparticle technology to identify adjuvants and enhance immune responses of those at the extremes of age in vitro and in vivo. Studies will employ in vitro modeling of human newborn, adult and elderly antigen-presenting cells, T and B lymphocytes as well as in vivo animal and human studies.

Our laboratory, comprised of 12 current members including post-doctoral scientists, clinical fellows and technicians, is dynamic, international, supportive and productive. We are well funded by NIH, Gates Foundation, internal support as well as multiple sponsored research agreements. We offer excellent opportunities for high impact research, publication, attendance at scientific meetings, and careeradvancement with graduates of the lab holding prominent positions in academia and industry. The candidate should have obtained their PhD within the last 1-3 years. Interested applicants should e-mail their CV and arrange to have 3 statements of reference e-mailed to: ofer.levy@childrens.harvard.edu.

A postdoctoral fellow position is available in the Epigenetics and Stem Cell Unit of the Laboratory of Translational Gerontology Branch, National Institute on Aging (NIA), National Institutes of Health (NIH).

Specific interests of the laboratory encompass defining mechanisms that underlie age associated changes of the hematopoietic stem cell compartment with a focus on epigenetic drivers and DNA damage.

Candidates should have a Ph.D. M.D. or D.V.M. with 0-3 years post-doc experience. 

  • Strong oral and written communication skills are a requirement
  • Expertise working with lenti-viruses and CRISPR/Cas9 technology is desirable, but more importantly, we are seeking team members with
  • a strong work ethic and the aspiration to understand mechanisms driving tissue-specific stem cell
  • phenotypes. 

Please visit https://scholar.google.com/citations?user=xDwht4QAAAAJ&hl=en for more information on the research interests of our group

Applicants should submit their CV including a list of publications, a cover letter containing a brief statement of how his/her expertise can contribute to the research on aging hematopoietic stem cells (<1 page), and the name and contact information of three references to: 

Isabel Beerman, Ph.D., at isabel.beerman@nih.gov

Candidates may need to complete an on-site interview process to present her/his data and meet with our current group members. The Institute’s dynamic research environment encourages trainees to collaborate with the over 12,000 resource-rich NIH labs focused on basic, translational, and clinical research. 

Though the position is free from the demands of obtaining grants and teaching, opportunities to do both are available

Salary is commensurate with experience and accomplishments, and also includes benefits such as health insurance for the trainee and his/her family, support for coursework related to the trainee's research, opportunities to present research at national/international meetings. In addition, the NIH Fellows Committee (FelCom) and the NIH Office of Intramural Training & Education (OITE) sponsor a wide range of career development programs.

DHHS and NIH are Equal Opportunity Employers. The NIH is dedicated to building a diverse community in its training and employment programs

Postdoctoral Fellowship in Vascular Biology and Genetics at Harvard Medical School

The D’Amato Lab of the Vascular Biology Program at Boston Children’s Hospital and Harvard Medical School is seeking a highly motivated post-doctoral researcher to study the genetic control of ocular angiogenesis. The project investigates candidate genes found to control angiogenesis in the mouse eye. These candidate genes were identified through genome-wide association studies (GWAS) of inbred mouse strains and further validated in zebrafish. The fellow will lead a program to verify and elucidate the mechanism of action of these genes. The ideal postdoc (MD or PhD) will have a strong background in molecular and mammalian genetics with an interest in vascular biology and ophthalmology. Candidates should be able to work independently and have strong English writing skills. Salary is commensurate with experience. Position is available immediately for two years with potential for renewal and is fully funded with benefits. 

If interested, please send via email a CV, a statement of research interests, as well as the names and contact information for three references to:

Dr. Robert D'Amato 
Vascular Biology Program 
Boston Children's Hospital
300 Longwood Ave
Boston, MA 02115

robert.damato@childrens.harvard.edu

Lab website: www.damatolab.com

Senior Research Director

Department Stem Cell Program; Medicine-Hematology/Oncology

Description:
Senior Research Director, George Daley Laboratory; http://daley.med.harvard.edu
Seeking a talented scientist to supervise a dynamic translational hematology research
laboratory at Boston Children’s Hospital and the Harvard Medical School. This position supports
the principal investigator in managing scientific operations, maintaining regulatory compliance,
and performing research and administrative functions. The position calls for a conscientious,
creative, adaptable individual with good writing skills, and is well suited to the ambitious
individual who wishes to remain active in biomedical research as a career scientist in a
supervisory role. Outstanding candidates will be considered for faculty appointment as
Instructor at Boston Children’s Hospital and Harvard Medical School.


Duties and responsibilities will include:

• Participating in scientific group meetings, strategic planning, grant writing, and publications;
• Assisting principal investigator in managing personnel, projects, and research infrastructure;
• Supervising research technician staff and routine laboratory operations such as
ordering/receiving, inventory, vivarium coverage, and special projects;
• Liaison to institutional officials/offices including laboratory and radiation safety, research
operations, human resources, animal welfare, facilities and maintenance, occupational health
and safety, sponsored projects, public affairs, government affairs, intellectual property,
general counsel, and fund raising (Foundation and Trust);
• Recruitment and mentoring of research and administrative staff;
• Generation and maintenance of regulatory approvals including human subjects (IRB),
laboratory animals (IACUC), biosafety (IBC), and human embryonic stem cells (ESCRO);
• Operational understanding of standard laboratory equipment including freezers, tissue
culture hoods, incubators, FACS machines, microscopes, and computers among others;
• Maintenance of publication-related reporting and deposition requirements including
PubMedCentral, NIHMS, and MyNCBI;
• Monitoring of laboratory e-mail account and responding as needed to inquiries regarding
available positions, tissue donation, reagents requests, and other areas;
• Maintenance of laboratory website (experience with Dreamweaver, Photoshop and Illustrator
helpful);
• Drafting and review of sections of grant funding applications and progress reports pertinent to
budget justification, vertebrate animals, human subjects, facilities/infrastructure, and key
personnel;
• Editing of manuscripts, funding applications, and other laboratory-related submissions;
• Strategic planning regarding capital equipment requisitions, purchases, and space allocation;
• Ability to contribute to ongoing research projects as needed;

Requirements:
• Advanced Degree; MD or PhD in a related discipline
• At least 5 years of post-doctoral research experience
• Excellent oral and written communication skills

Please forward CV and three references to Dr. George Daley, Boston Children's Hospital, 1
Blackfan Circle, 7th Floor, Boston, MA 02115; Tel: 617-919-2015;
Daley.Lab@childrens.harvard.edu

Status Full Time - 40 Hours Shift Day

Schedule Mon-Fri and occasional weekends as needed


Stem Cell Scientist

Location: South San Francisco, CA, USA

Summary: Senti Bio is seeking talented stem cell biologists to contribute to our early stage

projects, including the translation of novel technologies, protocol/process development, and

generation of pre-clinical data on key disease indications related to engineering of human stem

cells. A successful applicant will be able to independently drive a high risk/high impact research

program, work collaboratively with the broader scientific and business team to meet

milestones, and play a key role in building the culture of the company as it grows. Applicants

should have current knowledge of stem cell culture and differentiation tools and methods as

well as a mindset to deliver robust and practical solutions for long term commercial impact. We

are seeking individuals who are passionate about the future of “smart therapeutics” and have

the energy and boldness to thrive and grow in a startup environment.

Responsibilities:

  • Plan, perform, and interpret scientific experiments in a laboratory setting
  • Provide technical expertise and leadership in multiple parallel projects
  • Prepare regular presentations to the broader business and strategic team
  • Stay current with advanced molecular methods, scientific literature, and participate in

ideation and decision making meetings

  • Lead and propose “mini-projects” as needed, such as assessment of novel methods or

applications

  • Assist in milestone planning, budgeting, and team building/training

Qualifications:

  • Ph.D. or equivalent with expertise in stem cell biology or cell engineering
  • At least 2 years of stem cell engineering (ESC, iPSC, MSC, HSC), preferably for

therapeutic applications

  • Proficient with cell culture, cell analysis, and flow cytometry and analysis
  • Demonstrated ability to work independently and as part of a multi-functional team
  • Experience with in vivo animal studies a plus
  • Prior experience in a startup or industry role in therapeutic drug development a plus

Salary and Benefits:

  • Base pay, bonuses, and benefits to be determined based on application qualifications

with the aim of being competitive with similar roles in the area

  • Significant growth opportunity as the company expands

About: Senti Biosciences is a pioneering biotechnology startup developing novel therapeutics to

solve challenging and complex diseases. Founded in 2016 from an all-star team of synthetic

biologists from leading universities, Senti is creating world-class capabilities to design and

develop therapeutic cell circuits to improve human health. Headquartered in the San Francisco

Bay Area, Senti leverages expertise in bio-engineering and biological programming to build the

future of gene and cell based therapies.

To Apply:

Send an email with resume and cover letter to: jobs@sentibio.com


Aldovini lab:Division of Infectious Diseases at Boston Children's Hospital and Harvard Medical School

A postdoctoral position is available in the Division of Infectious Diseases at Boston Children’s Hospital and Harvard Medical School to support in a research program on HIV biology and AIDS vaccine development. Highly motivated applicants must have a PhD or MD degree, strong experience in molecular biology and/or immunology techniques and good communication skills. 

Send curriculum vitae with names and addresses of three references to Dr. Anna Aldovini: anna.aldovini@childrens.harvard.edu

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