Loddenkemper Research Laboratory


Tobias Loddenkemper of the Loddenkemper Lab sits on his desk.

Welcome to the Loddenkemper Lab.

Our mission is to prevent, predict, detect, and treat every seizure and status epilepticus in children before it occurs. We envision a world in which seizure freedom is achieved for all children through closed-loop early warnings/treatments and aim to provide critical data to further the understanding of epilepsy for medical professionals, families, and patients alike by using machine learning and predictive algorithms to prevent seizures and diffuse the stigma of the disease. As for clinical aims, we simply strive to provide the best care possible for pediatric patients with epilepsy.

Combined, these aims guide our work and help us develop epilepsy care from a largely inpatient driven population to continuous outpatient care, and integrate seizure monitoring tools for seizure detection/prediction in patients at greatest risk for complications such as status epilepticus and sudden, unexpected death in epilepsy (SUDEP). 

How do we do it?

  • Inventing, evaluating and implementing clinically relevant biomarkers and treatment paradigms to assess and benchmark these based on clinical data, neurophysiology, imaging, pharmacogenomics and genetics, in collaboration with basic researchers locally, nationally, and internationally.
  • Developing and evaluating monitoring tools for clinical biomarkers to further clinical epilepsy outcome measures including seizure characterization, neuropsychological outcome assessment, and quality of life assessment by means of seizure sensors and electronic tools including TriVox, the RENCI seizure tracking and outcome prediction modeling software, and novel in- and outpatient monitoring devices and algorithms, and neurophysiological, biochemical and genetic periodicity markers and implement these techniques into clinical workflow.
  • Research networks and collaborations are essential for our work, like the Pediatric Status Epilepticus Research Group, the Pediatric Epilepsy Research Consortium, the pediatric critical care epilepsy research group, the Critical Care EEG Monitoring Research Consortium, the Pediatric Neurocritical Care Research Group, and other consortia.


Click for a full list of Loddenkemper Lab publications on PubMed.