Overview

Dr. Harb works on the role of Notch signaling in allergic disease. He focuses on the effect of air pollutants i.e. particulate matter (PM) and their role in the exacerbation of airway inflammation and asthma. Furthermore, he tries to understand the different mechanisms the IL-4R mutation (Q576R) on asthma in children. His work covers both analyzing patient samples as well as studying airway inflammation in different mouse models.

Background

Dr. Harb has got his Bachelors in Pharmaceutical Sciences from Amman, Jordan. He then moved to Germany to join the lab of Prof. Harald Renz at the Philipps University Marburg at the department of Laboratory medicine and Pathobiochemistry. In his time there, he has finished his Masters in Infectious diseases with the focus on Immunology and Microbiology. Then then started his PhD in Immunology and Epigenetics in the same lab. His thesis focused on the role of different supplementary additives during pregnancy and their role in changing the epigenetic marks in the offspring in context of allergy and asthma. He finished his PhD with "Suma com Laude" in 2017, he moved to Boston to join Dr. Chatila's lab at Boston Children's hospital where he continued his work on allergy and asthma in the context of air pollution and its role in exacerbating the hallmarks of asthma. His work focuses on the role of Notch signaling in airway inflammation. He has published more than 25 publications. He serves as a co-chair of the Career Development Committee at the BCH Postdoctoral Association.

Researcher Services

Researcher Areas

  • Allergy
  • Asthma
  • Epigenetics
  • IL-4R
  • Notch signaling
  • Pollutants

Research Divisions

Researcher Labs

PUBLICATIONS

  1. Functional Reprogramming of Regulatory T cells in the absence of Foxp3. Louis-Marie Charbonnier, Ye Cui, Emmanuel Stephen-Victor, Hani Harb, David Lopez, Jack Bleesing, Maria Garcia-Lloret, Karin Chen, Ahmet Ozen, Peter Carmeliet, Ming Li, Matteo Pellegrini, Talal Chatila, Nature Immunology (Accepted)
  2. Microbiota Therapy Acts Via a Regulatory T Cell MyD88/ROR?t Pathway to Suppress Food Allergy. Azza Abdel-Gadir, Emmanuel Stephen-Victor, Georg K. Gerbe, Magali Noval Rivas, Sen Wang, Hani Harb, Leighanne Wang, Ning Li, Elena Crestani, Sara Spielman, William Secor, Heather Biehl, Nicholas Dibendetto, Xiaoxi Dong, Dale T. Umetsu, Lynn Bry, Rima Rachid and Talal A. Chatila
  3. Epigenetic Modifications in Placenta are Associated with the Child’s Sensitization to Allergens Hani Harb, Bilal Alashkar Alhamwe, Nathalie Acevedo, Paolo Frumento, Catharina Johansson, Lisa Eick, Nikos Papadogiannakis, Johan Alm, Harald Renz, Daniel P. Potaczek, and Annika Scheynius
  4. Treatment of severe persistent asthma with IL-6 receptor blockade. Esty B, Harb H, Bartnikas LM, Charbonnier LM, Massoud AH, Leon-Astudillo C, Visner G, Subramaniam M, Phipatanakul W, Chatila TA. J Allergy Clin Immunol Pract. 2019 Mar 15. pii: S2213-2198(19)30267-3. doi: 10.1016/j.jaip.2019.02.043
  5. Histone Acetylation of Immune Regulatory Genes in Human Placenta in Association with Maternal Intake of Olive Oil and Fish Consumption. Acevedo N, Frumento P, Harb H, Alashkar Alhamwe B, Johansson C, Eick L, Alm J, Renz H, Scheynius A, Potaczek DP. Int J Mol Sci. 2019 Mar 1;20(5). pii: E1060. doi: 10.3390/ijms20051060.
  6. Histone modifications and their role in epigenetics of atopy and allergic diseases. Alaskhar Alhamwe B, Khalaila R, Wolf J, von Bülow V, Harb H, Alhamdan F, Hii CS, Prescott SL, Ferrante A, Renz H, Garn H, Potaczek DP. Allergy Asthma Clin Immunol. 2018 May 23;14:39. doi: 10.1186/s13223-018-0259-4.
  7. A Jagged1-Notch4 Molecular Switch Mediates Airway Inflammation by Ultrafine Particles. Xia M, Harb H, Saffari A, Sioutas C, Chatila TA. J Allergy Clin Immunol. 2018 Apr 5. pii: S0091-6749(18)30510-4. doi: 10.1016/j.jaci.2018.03.009
  8. Assessment of Brain Derived Neurotrophic Factor in hair to study stress responses: A pilot investigation. H. Harb, M. González-de-la-Vara, L. Thalheimerd, U. Klein, H. Renz, M. Rose, J. Kruse, D.P. Potaczek, E.M.J. Peters. Psychoneuroendocrinology 2017 Sep
  9. The Microbial Metabolite Butyrate Induces Expression of Th1-Associated Factors in CD4+ T Cells. Kespohl M, Vachharajani N, Luu M, Harb H, Pautz S, Wolff S, Sillner N, Walker A, Schmitt-Kopplin P, Boettger T, Renz H, Offermanns S, Steinhoff U, Visekruna A. Front Immunol. 2017 Aug
  10. Aberrant cognitive phenotypes and altered hippocampal BDNF expression related to epigenetic modifications in mice lacking the post-synaptic scaffolding protein SHANK1: Implications for autism spectrum disorder. Sungur AÖ, Jochner MCE, Harb H, Kiliç A, Garn H, Schwarting RKW, Wöhr M. Hippocampus. 2017 Aug
  11. Epigenetics and allergy: from basic mechanisms to clinical applications. Potaczek DP, Harb H, Michel S, Alhamwe BA, Renz H, Tost J. Epigenomics. 2017 Mar 21. doi: 10.2217/epi-2016-0162. [Epub ahead of print]
  12. Chronic schistosomiasis during pregnancy epigenetically reprograms T cell differentiation in offspring of infected mothers. Klar K, Perchermeier S, Bhattacharjee S, Harb H, Adler T, Istvanffy R, Loffredo-Verde E, Oostendorp R, Renz H, Prazeres da Costa C. Eur J Immunol. 2017 Mar 8. doi: 10.1002/eji.201646836
  13. The role of PKC? in cord blood T-cell maturation towards Th1 cytokine profile and its epigenetic regulation by fish oil. Harb H, Irvine J, Amarasekera M, Hii CS, Kesper DA, Ma Y, D'Vaz N, Renz H, Potaczek DP, Prescott SL, Ferrante A. Biosci Rep. 2017 Feb 3. pii: BSR20160485. doi: 10.1042/BSR20160485
  14. The Role of Histone Protein Modifications and Mutations in Histone Modifiers in Pediatric B-Cell Progenitor Acute Lymphoblastic Leukemia. Janczar S, Janczar K, Pastorczak A, Harb H, Paige AJ, Zalewska-Szewczyk B, Danilewicz M, Mlynarski W. Cancers (Basel). 2017 Jan 3;9(1). pii: E2. doi: 10.3390/cancers9010002. Review.
  15. Recent developments in epigenetics of pediatric asthma. Harb H, Alashkar Alhamwe B, Garn H, Renz H, Potaczek DP. Curr Opin Pediatr. 2016 Dec;28(6):754-763.
  16. Draft Genome Sequence and Complete Plasmid Sequence of Acinetobacter lwoffii F78, an Isolate with Strong Allergy-Protective Properties. Fritzenwanker M, Hain T, Kesper DA, Harb H, Renz H, Domann E. Genome Announc. 2016 Jul 21;4(4).
  17. Epigenetic Regulation in Early Childhood: A Miniaturized and Validated Method to Assess Histone Acetylation. Harb H, Amarasekera M, Ashley S, Tulic MK, Pfefferle PI, Potaczek DP, Martino D, Kesper DA, Prescott SL, Renz H. Int Arch Allergy Immunol. 2015;168(3):173-81. doi: 10.1159/000442158.
  18. Transcription factor c-Rel plays a crucial role in driving anti-CD40-mediated innate colitis. Visekruna A, Linnerz T, Martinic V, Vachharajani N, Hartmann S, Harb H, Joeris T, Pfefferle PI, Hofer MJ, Steinhoff U. Mucosal Immunol. 2015 Mar;8(2):307-15. doi: 10.1038/mi.2014.68.
  19. Childhood allergic asthma is associated with increased IL-13 and FOXP3 histone acetylation. Harb H, Raedler D, Ballenberger N, Böck A, Kesper DA, Renz H, Schaub B. J Allergy Clin Immunol. 2015 Jul;136(1):200-2. doi: 10.1016/j.jaci.2015.01.027. Epub 2015 Mar 11. No abstract available.
  20. Update on epigenetics in allergic disease. Harb H, Renz H. J Allergy Clin Immunol. 2015 Jan;135(1):15-24. doi: 10.1016/j.jaci.2014.11.009. Review.
  21. Genome-wide DNA methylation profiling identifies a folate-sensitive region of differential methylation upstream of ZFP57-imprinting regulator in humans. Amarasekera M, Martino D, Ashley S, Harb H, Kesper D, Strickland D, Saffery R, Prescott SL. FASEB J. 2014 Sep;28(9):4068-76. doi: 10.1096/fj.13-249029. Epub 2014 Jun 2.
  22. Epigenetics in immune development and in allergic and autoimmune diseases. Martino D, Kesper DA, Amarasekera M, Harb H, Renz H, Prescott S. J Reprod Immunol. 2014 Oct;104-105:43-8. doi: 10.1016/j.jri.2014.05.003. Epub 2014 Jun 30. Review.
  23. Bioavailability and allergoprotective capacity of milk-associated conjugated linoleic acid in a murine model of allergic airway inflammation. Böcking C, Harb H, Ege MJ, Zehethofer N, Fischer K, Krauß J, Holst O, Nüsing RM, Lindner B, von Mutius E, Renz H, Garn H, Pfefferle PI. Int Arch Allergy Immunol. 2014;163(3):234-42. doi: 10.1159/000358523. Epub 2014 Mar 1.
  24. The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells. Raczkowski F, Ritter J, Heesch K, Schumacher V, Guralnik A, Höcker L, Raifer H, Klein M, Bopp T, Harb H, Kesper DA, Pfefferle PI, Grusdat M, Lang PA, Mittrücker HW, Huber M. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15019-24. doi: 10.1073/pnas.1309378110. Epub 2013 Aug 26.
  25. Neonatal supplementation of processed supernatant from Lactobacillus rhamnosus GG improves allergic airway inflammation in mice later in life. Harb H, van Tol EA, Heine H, Braaksma M, Gross G, Overkamp K, Hennen M, Alrifai M, Conrad ML, Renz H, Garn H. Clin Exp Allergy. 2013 Mar;43(3):353-64. doi: 10.1111/cea.12047.
  26. Farm-derived Gram-positive Bacterium Staphylococcus sciuri W620 prevents asthma phenotype in HDM- and OVA-exposed mice. Hagner S, Harb H, Zhao M, Stein K, Holst O, Ege MJ, Mayer M, Matthes J, Bauer J, von Mutius E, Renz H, Heine H, Pfefferle PI, Garn H. Allergy. 2013 Mar;68(3):322-9. doi: 10.1111/all.12094. Epub 2013 Feb 1.
  27. Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes. Brand S, Teich R, Dicke T, Harb H, Yildirim AÖ, Tost J, Schneider-Stock R, Waterland RA, Bauer UM, von Mutius E, Garn H, Pfefferle PI, Renz H. J Allergy Clin Immunol. 2011 Sep;128(3):618-25.e1-7. doi: 10.1016/j.jaci.2011.04.035. Epub 2011 Jun 15.
  28. Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma.Tachdjian R, Mathias C, Al Khatib S, Bryce PJ, Kim HS, Blaeser F, O'Connor BD, Rzymkiewicz D, Chen A, Holtzman MJ, Hershey GK, Garn H, Harb H, Renz H, Oettgen HC, Chatila TA. J Exp Med. 2009 Sep 28;206(10):2191-204. doi: 10.1084/jem.20091480. Epub 2009 Sep 21.